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One novel naphthalene derivative, 2-octa-2′,4′,6′-atriynenaphthalene ( 1 ), together with eighteen known compounds ( 2 – 19 ) were isolated from the aerial parts of  Dracocephalum moldavica  L. Compounds  2 ,  8 ,  10 ,  13 ,  15 – 17  and  19  were obtained from the family Lamiaceae for the first time, and compounds  11  and  18  were firstly identified from the genus of  Dracocephalum . All the isolates were evaluated for anti-complementary activities through the classical and alternative pathways, and the targets of the most active compounds on the complement activation cascade were also investigated.

One novel naphthalene derivative and other constituents with anti-complementary activities from the aerial parts of Dracocephalum moldavica