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One new citrinin monomer derivative ( 1 ), and two new natural products α-pyrone analogues ( 2a  and  2b ), were isolated from the sponge derived fungus  Penicillium  sp. SCSIO 41302. Their structures were determined by extensive spectroscopic analysis, chiral-phase HPLC analysis, modified Mosher’s method, ECD calculations, and X-ray single-crystal diffraction. Bioactivity screening showed that compounds  2b  and  8  exhibited obvious inhibitory activities against pancreatic lipase and acetyl cholinesterase with IC 50  values of 48.5 and 4.8 μM, respectively, which indicated that different chiral center between enantiomers ( 2a  and  2b ) might result in different biological activities (IC 50  value against PL for  2a  &gt;100 μg/ml).

Citrinin and α-pyrone derivatives with pancreatic lipase inhibitory activities from Penicillium sp. SCSIO 41302