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Three new polyketide derivatives, 2-ethoxycarbonyl-endocrocin ( 1 ), 6-methoxy-2-ethoxycarbonyl-endocrocin ( 2 ) and pannorin C ( 3 ), along with sixteen known compounds ( 4–19 ) were isolated from a plant endophytic fungus  Aspergillus cristatus  2H1. Their structures were elucidated by 1D/2D NMR and HR-ESI-MS data analysis. Compound  3  showed weak antibacterial activity against  Staphylococcus aureus  (MIC 20 μg/ml). Compounds  14  and  15  showed effective cytotoxicity on human melanoma A375 cells (IC 50  4.13 μM for  14 , 3.39 μM for  15 ).

Three new polyketide derivatives of the endophytic fungus Aspergillus cristatus 2H1