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Two new prenylated xanthones, mangoxanthones A-B ( 1 - 2 ), together with four known compounds  3 - 6 , were isolated from the ethanol extract of the pericarp of  Garcinia mangostana . The structures of these compounds have been elucidated based on spectroscopic analysis. The analysis results of chiral HPLC revealed compounds  1  and  2  were scalemic mixtures respectively. All isolated compounds were biologically evaluated for their α-glucosidase and α-amylase inhibitory effects using  in-vitro  assays. Compound  1  showed moderate inhibitory activities against α-glucosidase and α-amylase with IC 50  of 29.06 ± 1.86 and 22.74 ± 2.07 μM, respectively. Molecular docking predicted the binding sites of compound  1  to α-glucosidase and α-amylase. A preliminary structure-activity relationship was discussed.

Prenylated xanthones with α-glucosidase and α-amylase inhibitory effects from the pericarp of Garcinia mangostana