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Seven benzophenone compounds were synthesized in one or two steps, then their antitumor activity was evaluated. The total yields ranged from 9% to 44%. Compounds  3c–5c  exhibited obvious antitumor activity. Among them, compounds  3c  and  4c  exhibited excellent and broad-spectrum antitumor activity. Compound  3c  exhibited much stronger inhibitory activities against fourteen cancer cells than cisplatin. In particular, compound  3c  exhibited stronger cytotoxicity against hepatocarcinoma SMMC-7721 cells than Taxol, with a half maximal inhibitory concentration (IC 50 ) of approximately 0.111 μM. These results demonstrated that compounds  3c ,  4c  and  5c  were very promising antitumor leads for further structural modification.

Synthesis and antitumor activity of benzophenone compound