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In this study, a liquid chromatography-tandem multi-stage mass spectrometry (LC/MS n ) method was established to characterize the metabolites of TRG in monkeys and dogs. A total of seven metabolites of TRG besides the prototype were found, which were identified as TR (M1), TRN (M2),  trans -resveratrol-4'- O -glucuronide (M2'),  trans -resveratrol-3- O -glucoside-4'- O -glucuronide (M3),  trans -resveratrol-3- O -glucoside-5- O -glucuronide (M3'),  trans -resveratrol-3-sulfate (M4) and  trans -resveratrol-4'-sulfate (M4'). Additionally, the metabolic pathways of TRG in monkeys and dogs were proposed. There were also species differences of metabolism of TRG between monkeys and dogs.

Characterization of the metabolites of trans -resveratrol-3- O -glucoside in monkeys and dogs