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Natural compounds bearing maleimide rings are a series of secondary metabolites derived from fungi/marine microorganisms, which are characterized by a general structure –CO–N( R )–CO–, and the  R  group is normally substituted with alkyl or aryl groups. Maleimide compounds show various biological activities such as antibacterial, antifungal, and anticancer activity. In this review, the broad-spectrum antimicrobial activities of 15 maleimide compounds from natural sources and 32 artificially synthesized maleimides were summarized, especially against  Candida albicans ,  Sclerotinia sclerotiorum , and  Staphylococcus aureus . It highlights that maleimide scaffold has tremendous potential to be utilized in the development of novel antimicrobial agents.

Maleimide structure: a promising scaffold for the development of antimicrobial agents