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Mangrove endophytic fungi were proved to be a prolific resources for bioactive secondary metabolites. Two new polyketides, pestalotiopin B ( 1 ) and pestalotiopyrone N ( 2 ) were obtained from the ethyl acetate extracts of the rice solid cultures of the mangrove endophytic fungus  Pestalotiopsis  sp. HQD-6. The structures of  1  and  2  were determined by detailed interpretation of NMR spectroscopic analysis and HR-ESIMS. All of the isolates were evaluated for their antimicrobial, antioxidant and cytotoxic activities.

Two new polyketides from endophytic fungus Pestalotiopsis sp. HQD-6 isolated from the Chinese mangrove plant Rhizophora mucronata