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Two new flavonoid glycosides named 6-hydroxy-3-methoxy-apigenin 7- O - α -ʟ-rhamnopyranoside ( 1 ) and 3-hydroxyl-apigenin 8-C- β -ᴅ-xylopyranoside ( 2 ), along with five known compounds ( 3-7 ), were isolated from  Xanthium strumarium . Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All compounds were evaluated for  in vitro  inhibitory activity against PTP1B. Among them, compounds  1  and  5  showed significant inhibitory activity on PTP1B with IC 50  values of 11.3 ± 1.7 and 8.9 ± 0.7 μM, respectively.

New flavonoid glycosides from Xanthium strumarium with their protein tyrosine phosphatase 1B inhibitory activity