Open AccessSpatial Tumor‐Immune Modeling
Author(s) -
L. G. de Pillis,
Dann Mallet,
Ami Radunskaya
Publication year - 2006
Publication title -
computational and mathematical methods in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.462
H-Index - 48
eISSN - 1748-6718
pISSN - 1748-670X
DOI - 10.1080/10273660600968978
Subject(s) - immune system , computer science , geography , biology , immunology
In this paper, we carry out an examination of four mechanisms that can potentially lead to changing morphologies in a growing tumor: variations in nutrient consumption rates, cellular adhesion, excessive consumption of nutrients by tumor cells and immune cell interactions with the tumor. We present numerical simulations using a hybrid PDE-cellular automata (CA) model demonstrating the effects of each mechanism before discussing hypotheses about the contribution of each mechanism to morphology change
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