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There is compelling evidence that substrate stiffness affects cell adhesionas well as cytoskeleton organization and contractile activity. This work wasdesigned to study the cytoskeletal contractile activity of cells plated onmicroposts of different stiffness using a numerical model simulating theintracellular tension of individual cells. We allowed cells to adhere ontomicropost substrates of various rigidities and used experimental traction forcedata to infer cell contractility using a numerical model. The modeldiscriminates between the influence of substrate stiffness on cell tension andshows that higher substrate stiffness leads to an increase in intracellulartension. The strength of this model is its ability to calculate the mechanicalstate of each cell in accordance to its individual cytoskeletal structure. Thisis achieved by regenerating a numerical cytoskeleton based

The consequence of substrates of large-scale rigidity on actin network tension in adherent cells