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Cinnamomum glanduliferum  is an aromatic evergreen plant of family Lauraceae. In this work, various drying conditions like sun, shade and oven (at 40°C and 50°C) were used to explore the variation in the essential oil composition, antioxidant, anti-inflammatory, anti-diabetic activities, as well as  in silico  ADMET and molecular docking study of leaves of the  C. glanduliferum  species. Fresh and dried samples were hydro-distilled using Clevenger equipment, and the resulting essential oil was analysed by GC and GC-MS. Egg albumin was used to perform  in-vitro  anti-inflammatory action. The antioxidant capacity was evaluated using DPPH radical scavenging, H 2 O 2  radical scavenging, and iron metal chelating activities. α-Amylase inhibition activity was also performed on all samples. 1,8-Cineole (44.26 to 58.80%), sabinene (16.68 to 20.50%), and α-terpineol (9.04 to 10.50%) were the main components of the oils of the dried samples. The shade-dried sample had the highest essential oil yield, followed by the sun-dried, oven-dried at 50°C, and oven-dried at 40°C. The maximum antioxidant and α-amylase inhibitory activities were demonstrated by oven -dried plant material at 40°C, whereas the lowest activities were exhibited by an oven sample at 50°C. On the other hand, oven dried samples at 50°C had the highest anti-inflammatory activity; while oven dried samples at 40°C had the lowest. Drying procedures influenced essential oil composition and yield. The sample dried in an oven at 40°C preserved the most 1,8-cineole, indicating it the most effective drying method for  C. glanduliferum . Furthermore, the oven 40°C sample demonstrated significant antioxidant and anti-diabetic activities.

journal of essential oil bearing plants

Chemical composition, antioxidant, anti-inflammatory, anti-diabetic activities,  in silico  PASS, ADMET study and molecular docking of essential oils from  Cinnamomum glanduliferum  at various drying conditions