English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Essential oils (EOs) extracted from aromatic plants are a potential source of several bioactive compounds. In the present study, hydro-distillation of  Apium graveolens  essential oil (AG-EO) was carried out and its chemical constituents were analyzed using Gas Chromatography (GC) and Gas Chromatography-Mass spectrometry (GC/MS) followed by examination of its antifungal, antioxidant, and cytotoxic potential against human breast cancer cells, MDA-MB-231. Analysis of EO resulted in the identification of nineteen (19) compounds majorly in 1,2-diphenyl-1,2-ethanediol (65.2%), 3-butyl phthalide (9.1%), limonene (6.4%), 1,1-dimethyl-1,2,3,5,7,8,9,9a-octahydro-benzocyclohepten-6-one (5.6%). Further, antifungal activity of  A. graveolens  EO (AG-EO) against three soil borne phytopathogenic fungal strains namely  Fusarium oxysporum, Curvularia lunata , and  Sclerotinia sclerotiorum  showed significant mycelial growth inhibition at a concentration of 500 μg/mL with IC 50  value ranging between 966-220.76 μg/mL. The antioxidant potential of EO was evaluated using dedicated spectrophotometric assays such as FRAP and DPPH. Results revealed the free radical scavenging potential of AG - EO with the value of 7.71±0.04 mM AAE/100g (for DPPH assay) and 8.31±0.03 mM AAE/100g (for FRAP assay). Additionally, the percentage of cell survival of MDA-MD-231 human breast cancer cells after treatment with EO was about 68% at 24h showing the cytotoxic effect of AG-EO against breast cancer cells whereas for non-malignant control HEK 293T cells it was about 83%. The present study indicated that the antioxidant, antifungal, and cytotoxic potential of AG - EO, a natural source of bioactive compounds, could be employed in the food, pharmaceuticals, agriculture, and cosmetics industries. However, further evaluations on animal models and clinical studies are warranted.

journal of essential oil bearing plants

Chemical Composition, Antifungal, Antioxidant and Cytotoxic Potential of  Apium graveolens  L. (Celery) Leaves Essential Oil Collected from Nainital, Uttarakhand