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This study was conducted to determine the influence of nano zinc oxide (N-ZnO) on metabolic parameters in transition periods of the Lacaune ewes. The animals were allocated into two equal groups: the control group ( n  = 10) and the experimental group ( n  = 10) supplemented with 20 mg/kg of N-ZnO. Blood samples were collected from all ewes on days −30, −15, 0 (parturition), + 15 and +30. A time effect was observed on aspartate aminotransferase which decreased in both groups from day −30 to day 0 ( P  ≤ 0.05). All ewes on day 0 had lower alanine aminotransferase than on day −30 ( P  ≤ 0.001) and day −15 ( P  ≤ 0.05). In both groups, albumin and total protein levels on day −30, blood urea nitrogen level on day +30 ( P  ≤ 0.001), β-hydroxybutyric acid and non-esterified fatty acid levels on day +15 ( P  ≤ 0.05) were higher. Triglycerides on day +30, glucose on days −15, 0, + 30 were lower ( P  ≤ 0.001). Blood calcium was lower ( P  ≤ 0.05) and zinc was higher on day +30 ( P  ≤ 0.001). In conclusion, there was no significant effect of N-ZnO/kg supplementation during the transition period, but changes in metabolic parameters due to a time effect were observed.

Effects of nano zinc oxide supplementation on metabolic parameters during the transition period in Lacaune ewes