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Rice sheath blight, caused by  Rhizoctonia solani , is one of the increasing concerns in rice causing severe economic losses worldwide. Chemical control measures are already in practice for the management of this disease but approach for discovery of new chemicals with improved disease control potential is essential. The present investigation involves the development of nanoformulations of halogen substituted azomethines as new potent fungicide for the management of sheath blight disease in rice. The halogen substituted azomethines were synthesized and screened for  in-vitro  bioefficacy. Then the azomethines were nanoformulated for their  in-vivo  pot culture evaluation against  Rhizoctonia solani . Transmission electron microscopy confirmed the particle size of the developed nanoformulations in the range of 1–100 nm.  In-vitro  inhibition results of test compounds revealed their ED 50  values in the range of 11.9 to 22.4 μg/ml with best performer 2,4,5-trichloro-N-(2,4-dichlorobenzylidene)aniline. 3-Chloro-N-(2,6-dichlorobenzylidene)-4-fluoroaniline displayed maximum  in-vivo  efficacy against  R. Solani  which was comparable with that of hexaconazole, a standard recommended fungicide.

New nano-fungicides for the management of sheath blight disease ( Rhizoctonia solani ) in rice