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In-vitro  evidence suggests that the lipid component of foods alters vitamin D absorption. This single-blinded, cross-over postprandial study examined the effect of changing the lipid component of a 20 µg vitamin D 3  fortified dairy drink on postprandial 25(OH)D concentrations. Participants consumed one dairy drink per visit: a non-lipid, a pre-formed oleic acid micelle, an olive oil and a fish oil dairy drink. There was a significant time*drink*baseline status effect on 25(OH)D concentrations ( p  = 0.039). There were no time*drink, time or drink effects on 25(OH)D in vitamin D sufficient participants (&gt;50nmol/L). However, there was an effect of time on changes in 25(OH)D concentrations after the olive oil dairy drink ( p  = 0.034) in vitamin D insufficient participants (&lt;50nmol/L). There were no effects after the other diary drinks. Olive oil may improve vitamin D absorption from fortified foods. Further research is needed to examine the practical implications of changing the lipid component of fortified foods.

Postprandial 25-hydroxyvitamin D response varies according to the lipid composition of a vitamin D3 fortified dairy drink