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Though the ideas of health and sickness are very much at the heart of Nietzsche’s mature thought, scholars have offered little on what exactly he means by sickness. This is particularly true when Nietzsche presents his conception of sickness in more narrowly physiological terms, as he does explicitly in the Third Essay of  On the Genealogy of Morality . In this paper, I present an account of what Nietzsche means by physiological sickliness and sickness, and how these notions are related to asceticism. In particular, I argue that for Nietzsche human beings have been subject through all of history to epidemics of nervous inhibition and exhaustion. In explaining these physiological conditions, I detail the basic understanding of the nervous system in the nineteenth century and show how Nietzsche’s diagnosis of sickness in this system explains many of the mysterious elements of the Third Essay. In my final section, I sketch out the meaning of the ascetic ideal against the backdrop of this nervous sickness.

Patterns of sickness: Nietzsche’s physio-historical account of asceticism