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Origanum munzurense  ( O. munzurense ) is an endemic species of Tunceli region of Turkey. In this study, we investigated  in vitro  anticancer effect of aqueous extract of  O. munzurense  (OME) on breast cancer cells (MCF-7).  In vitro  cytotoxic effect of OME was evaluated in MCF-7 cells by MTT assay. The wound-healing assay was used to examine the inhibition of migration. Annexin V/propidium iodide staining, cell-cycle distribution was assessed by flow cytometry for MCF-7 cells treated with OME. MTT results show that OME demonstrated in vitro cytotoxicity with 600 mg at 48 h on MCF-7. Doses of 400 µg/mL and 600 µg/mL OME significantly suppressed the migration rate of MCF-7 cells. OME significantly decreased the percentage of live cancer cells and showed an apoptotic effect after 48 h of incubation. These results show that OME is effective against breast cancer when administered at high doses and for a long time.

Anticancer potential of Origanum munzurense extract against MCF-7 breast cancer cell