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Limonium  genus is traditionally used in North Africa for disease treatment and in cosmetic. This study investigates for the first time the antioxidant, anti-inflammatory and enzyme inhibitory activities of two Tunisian endemic plants,  L. boitardii  and  L. cercinense . Analysis of phenolic compounds was carried out by using RP-HPLC. Total phenolic and flavonoid contents, antioxidant activity (antiradical, reducing and total antioxidant activities), tyrosinase and α-glucosidase, collagenase inhibition activities were determined. Inhibiting of NO release in LPS-stimulated macrophages was assessed.  L. cercinense  exhibited strong antioxidant and anti-inflammatory effects. In the tyrosinase and α-glucosidase inhibitor activity tests, the two species were highly active, especially  L. cercinense . High total phenolic and flavonoid contents were recorded in  L. cercinense  and myricitrin, myricetin, myricetin 3- O -β-D-galatopyranoside, luteolin 7- O -glucoside and rutin were the main phenolics in both species. The results obtained render  L. boitardii  and  L. cercinense  as valuable new natural sources for cosmetic and pharmacological applications.

international journal of environmental health research

Bioactivities and phenolic composition of  Limonium boitardii  Maire and  L. cercinense  Brullo &amp; Erben (Plumbaginaceae): two Tunisian strict endemic plants