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The interaction manner of  Prunus mahaleb  L. ( P. mahaleb ) seed oil (MSO) and fluconazole (FLC: antimycotic) combinations (MSO*FLC) against C.  albicans  and C.  parapsilosis  were evaluated using the microdilution technique. The most representative compounds of mahaleb oil were found to be conjugated linolenic acid (34.39%), oleic acid (31.76%), and linoleic acid (25.54%) by GC-MS. In antimicrobial activity study,  P. mahaleb  had an inhibition zone (IZ) of C.  albicans  and C.  parapsilosis  with 6.89 mm and 11.39 mm and a minimum inhibitory concentration (MIC) with 35.3 µgmL −1  and 23.9 µgmL −1 , respectively. The strongest indifferent effect was observed as 57.14% for  C. albicans  and 100% for  C. parapsilosis  in fluconazole-mahaleb oil combinations. An increase in DNA and protein leakage was observed when yeast was exposed to the FA. The destruction on the cell surface was visualized using Scanning Electron Microscopy (SEM) analysis.

Chemical composition, antifungal activity, antifungal mechanism and interaction manner of the fatty acid of Prunus mahaleb L. with fluconazole