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The purpose of this study was to investigate and compare the antioxidant and cytotoxic activities of  Sarcosphaera crassa  and  Tricholoma terreum  extracts. Phenolic compounds analysis of both mushroom extracts has been carried out by HPLC. Antioxidant activities of the extracts were tested by using  in vitro  assays. The cytotoxicity of extracts on HT-29 cell line were determined by the WST assay. The total phenolic and total flavonoid contents of  T. terreum  extracts were higher than those  S. crassa . Also, we detected that  T. terreum  extracts had higher total antioxidant activity and scavenging ability on DPPH radicals than  S. crassa  extracts. However, the  T. terreum  methanol extracts showed 27% cytotoxic effect in HT-29 cell line whereas the ethanolic extracts of  S. crassa  showed cytotoxicity 45%. These results indicate that both mushroom extracts have considerable cytotoxic and antioxidant properties and may be utilized as a promising source of therapeutics.

international journal of environmental health research

Cytotoxicity of  Sarcosphaera crassa  and  Tricholoma terreum  extracts on colon cancer cell line (HT-29) in conjunction with their antioxidant properties