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To explore the association between polymorphisms in microRNAs (miRNAs) and the cholinesterase (ChE) activity in omethoate-exposed workers, we recruited 180 omethoate-exposed workers and 115 controls to measure their ChE activity using acetylcholine and dithio-bis-(nitrobenzoic acid) and genotype susceptible SNPs in their miRNA by time-of-flight mass spectrometry. ChE activity in the exposure group was lower than that in the control group ( P  &lt; 0.001). The analysis of covariance result showed that ChE activity was lower in the (- -/- T) genotype in  miR-30a  rs111456995 (1.97 ± 0.47) than in the TT genotype (2.23 ± 0.59) of the exposure group ( P  = 0.004). Multivariate linear regression was performed to find influencing factors on ChE activity, and variables kept in the model included omethoate exposure ( b  = −1.094,  P  &lt; 0.001), gender ( b  = −0.381,  P  &lt; 0.001),  miR-30a  rs111456995 (- -/- T)( b  = −0.248,  P  &lt; 0.001), and drinking ( b  = 0.258,  P  =0.019). The results suggest that individuals carrying a (- -/- T) genotype in  miR-30a  rs111456995 were more susceptible to damage in their cholinesterase induced by omethoate exposure.

The association between polymorphisms in miRNA and the cholinesterase activity of workers in an omethoate-exposed environment