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Cognitive impairments figure prominently in COVID-19 survivors. Cognitive remediation therapy (CRT) improves functional outcomes reducing long-term cognitive deficits in several neurological and psychiatric conditions. Our case-control study investigates the efficacy of a CRT programme administered to COVID-19 survivors in the post-acute phase of the illness. Seventy-three COVID-19 survivors presenting cognitive impairments at one-month follow-up were enrolled. Among them, 15 patients were treated with a two-month CRT programme, and 30 non-treated patients were matched conditional to their baseline cognitive functioning. Cognitive functions were assessed before and after treatment. Depression and quality of life were also evaluated. Mixed model ANOVA revealed a significant effect over time of the CRT programme on global cognitive functioning ( F  = 4.56,  p  = 0.039), while no significant effect was observed in the untreated group. We observed a significant effect of the improvement in verbal fluency ( χ2  = 7.20,  p  = 0.007) and executive functions ( χ2  = 13.63,  p  &lt; 0.001) on quality of life. A positive significant correlation was found between depressive symptomatology and verbal fluency ( r  = −0.35), working memory ( r  = −0.44), psychomotor coordination ( r   = −0.42), and executive functions ( r   = −0.33). Our results could pave the way to a plausible innovative treatment targeting cognitive impairments and ameliorating the quality of life of COVID-19 survivors.

Cognitive remediation therapy for post-acute persistent cognitive deficits in COVID-19 survivors: A proof-of-concept study