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Oxygen uptake (V̇O 2 ) kinetics have been shown to be slowed in adolescents with cystic fibrosis (CF) during heavy-intensity cycling and maximal exercise testing. This study investigated V̇O 2  kinetics in adolescents with CF compared to control adolescents (CON) during a treadmill-walking exercise. Eight adolescents with CF and mild-to-moderate pulmonary obstruction (5 girls; 13.1 ± 2.5 years; FEV 1  67.8 ± 21.4%) and 18 CON adolescents (10 girls; 13.8 ± 1.8 years) were recruited. Pulmonary gas exchange and ventilation were measured during a single transition of 10 min of treadmill walking and a 5 min seated recovery period. Participant’s walking speed was determined during a one-minute self-paced walking task along a 50-m corridor. A six-parameter, non-linear regression model was used to describe the changes in V̇O 2  function during the treadmill walking and recovery, with monoexponential curve fitting used to describe the mean response time (MRT 1 ) at the onset of exercise, and the half-life (T 1/2 V̇O 2 ) at the offset of exercise. V̇O 2  baseline and amplitude, minute ventilation and respiratory equivalents were recorded. V̇O 2  kinetics were slower in CF group compared to CON group during the treadmill walking with a greater MRT 1  (32 ± 14 s vs 21 ± 16 s;  p  = .04, effect size = 0.75). The T 1/2 V̇O2 was prolonged during recovery in CF group compared to CON group (86 ± 24 s vs 56 ± 22 s;  p  = .04, effect size = 1.31). The mean VE/V̇CO 2  during exercise was the only parameter significantly greater in CF group compared to CON group (32.9 ± 2.3 vs 29.0 ± 2.4;  p  &lt; .01, effect size = 1.66). V̇O 2  kinetics were found to be slowed in adolescents with CF during treadmill walking.

Oxygen uptake kinetics during treadmill walking in adolescents with clinically stable cystic fibrosis