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To examine the reliability to model cellular S-values for the Auger electron (AE) emitters,  111 In,  197 Hg and  197m Hg with MCNP6 and their relative dose deposition in subcellular targets. A model cell was defined as four concentric spheres consisting of the nucleus (N), cytoplasm (Cy), cell and nuclear membranes (CM, NM) in which radionuclides distributed homogeneously. The transport of AE, conversion electrons and photons were simulated by MCNP6 to calculate cellular S values (S N←CM , S N←Cy , S N←NM , S N←N , S CM←CM , S NM←NM ). S N←CM , S N←Cy  and S N←N  were also calculated with MIRDcell. MIRDcell and MCNP6-calculated S N←N  were in excellent agreement, but a slight discrepancy on S N←Cy  and S N←CM  was observed. The ratios of S CM←CM  or S NM←NM  vs. S N←N  were 9.7–51.0 or 10.5–37.4, 7.9–41.8 or 8.4–31.8 and 7.2–36.9 or 8.0–28.1 for  111 In,  197 Hg,  197m Hg, respectively. The mean S( 197 Hg)/S( 111 In) and S( 197m Hg)/S( 111 In) were 2.5 ± 0.5 and 2.5 ± 0.6, respectively. Cellular S-values were reliably calculated with MCNP6.  197 Hg and  197m Hg deposit two-fold more doses than  111 In at the subcellular scale. All AE emitters deposit a higher self-dose in the CM and NM than in the N, which warrants studies on the effects of targeting the CM and NM by AE emitters.

international journal of radiation biology

Cellular dosimetry of  197 Hg,  197m Hg and  111 In: comparison of dose deposition and identification of the cell and nuclear membrane as important targets