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Fumaric acid esters (FAEs) are a well-established treatment option for long-term therapy of moderate to severe plaque psoriasis. This study examines effectiveness of FAEs for the treatment of plaque psoriasis in real-world practice at 12 months and if patient characteristics affect the odds of clinical response. A descriptive, multivariable logistic regression analysis was conducted in a cohort drawn from the German registry PsoBest. Baseline patient characteristics were assessed as potential treatment effect modifiers. 444 patients (mean age 47.0 years, 39.0% female) were eligible for response analysis using nonresponder imputation at month 12. Of these, 39.6% achieved clinical response, i.e. Psoriasis Area and Severity Index (PASI) ≤ 3 or skin clearance. In logistic regression analysis ( R2  = 0.114), only baseline PASI was a significant factor: patients with PASI &lt; 10 had a 4 times higher odds ( p  ≤ .001, OR 4.088), patients with PASI of 10–20 a twofold higher odds of response ( p  ≤ .044, OR 1.961) compared to those with PASI &gt; 20. Neither sex, age, body weight, disease duration, comorbidity nor pretreatment had an impact on the odds of response ( p  &gt; .05). FAEs showed a favorable response at 12 months, largely independent of patient characteristics.

journal of dermatological treatment

Response to fumaric acid esters for plaque type psoriasis in real-world practice is largely independent of patient characteristics at baseline – a multivariable regression analysis from the German Psoriasis Registry PsoBest