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The eutectic mixture of local anesthetics (EMLA) is an effective cutaneous anesthetic, although its application is time consuming and poses a risk of methemoglobinemia. Currently, the efficacy of topical 10% lidocaine cream is unclear. To compare the onset, anesthesia depth, and duration of topical 10% lidocaine and EMLA cream. The randomized, split-body, comparative trial performed on 40 participants who received a topical 10% lidocaine cream or EMLA on forearms for 15–150 min. Pain was stimulated using a 21-gauge needle insertion and evaluated with the Verbal Pain Score. Adverse effects were recorded. EMLA conferred significantly better efficacy than 10% lidocaine ( p  &lt; .001). For acceptable pain at 4-mm depth, the minimal application times were 40.88 and 45.38 min of EMLA and 10% lidocaine creams, respectively. With 60/120-min application, the maximal needle-insertion depths with acceptable pain were 6.61/9.47 mm (EMLA) and 6.01/8.94 mm (10% lidocaine). EMLA’s anesthetic effect showed an early increase after removal which was sustained for 60–90 min. Both creams caused adverse effects, with EMLA showing higher proportions, although the differences were statistically insignificant. The efficacy of EMLA was superior to 10% lidocaine cream, especially regarding anesthesia onset and duration.

journal of dermatological treatment

Comparison of the onset, depth, and duration of cutaneous anesthesia between topical 10% lidocaine and EMLA creams: a randomized, intraindividual, comparative trial