English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Frontal fibrosing alopecia (FFA) is a scarring alopecia with no promising treatment. To evaluate the additive efficacy of oral isotretinoin to topical treatments. Between November 2017 and August 2018, FFA patients were randomly assigned to receive either isotretinoin (20 mg/d) plus topical treatments (clobetasol 0.05% and tacrolimus 0.1%) or monotherapy with topical treatments. Treatments’ efficacy was evaluated through Frontal Fibrosing Alopecia Severity Index (FFASI) after two and 6 months. From 38 participants, 28 patients completed the study. Facial papules improved after 6 months ( p  value &lt; .001) in the isotretinoin group. Moreover, frontotemporal hairline ( p  values for frontal &lt; .001; R lateral: 0.03; L Lateral: 0.02), total scalp margins, total additional features’ scores, and total combined ( p  value &lt; .001 for all) improved more in the isotretinoin group than in the control group. Frontal band improved in the treatment group ( p  value: .02). Frontal margin ( p  value: .01), R lateral ( p  value: .01), total scalp ( p  value &lt; .01), and combined total scores ( p  value: .01) worsened in the control group. Isotretinoin-related side-effects included lip dryness, telogen effluvium, and malaise. Small sample size and lost to follow-up. Isotretinoin combined with topical treatments is more effective than monotherapy with clobetasol and tacrolimus for FFA. (IRCT.ir) IRCT2017091736173N1.

journal of dermatological treatment

Oral isotretinoin combined with topical clobetasol 0.05% and tacrolimus 0.1% for the treatment of frontal fibrosing alopecia: a randomized controlled trial