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The microbe  Paecilomyces cicadae  (Miquel) Samson ( P. cicadae ) is an asexual strain of  Cordyceps cicadae  ( C. cicadae ) used in traditional Chinese medicine. Due to the abundance of secondary metabolites found in cultured metabolites, including polysaccharides, hyaluronic acid, ergosterol peroxide, and active nucleosides,  P. cicadae and/or C. cicadae  exhibit several therapeutic activities, including immunoregulatory, antioxidant, and anti-diabetic effects. Given the great attention for health care and the desirable medical value of  C. cicadae  and/or  P. cicadae,  they are becoming potential alternatives of  Cordyceps sinensis  ( C. sinensis ). Although there are many studies on  P. cicadae / C. cicadae , most of them are experimental research articles. There are limited reviews to summarize the latest researches on  P. cicadae / C. cicadae . This review mainly focuses on the metabolites, physiological activities and mechanisms of action of  P. cicadae  and/or  C. cicadae . This review can serve as a theoretical basis for the more efficient use of this medicinal fungus.

Paecilomyces cicadae : a systematic overview of the biological activities and potential mechanisms of its active metabolites