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Objective:  The effect of antioxidant supplements on glucose metabolism and lipid profiles in polycystic ovary syndrome (PCOS) remains controversial. This systematic review and meta-analysis aimed to evaluate whether antioxidant supplements improve glucose metabolism and lipid profiles in women with PCOS to provide optimal nutritional supplement advice in clinical practice.  Methods:  The search was conducted across multiple medical databases from inception to January 1, 2022 and performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A random effects model was used to calculate the overall effects.  Results:  Eighteen trials (1113 participants) were included. Antioxidant supplements significantly improved insulin resistance (95% CI, −0.62, −0.30;  p  &lt; 0.00001; I 2  =48%), fasting insulin (95% CI, −0.80, −0.44;  p  &lt; 0.00001; I 2  = 48%), and fasting plasma glucose (95% CI, −0.54, −0.21;  p  &lt; 0.00001; I 2  = 38%) in patients with PCOS. However, antioxidant supplements were found to not improve most indices of lipid profiles in PCOS except triglyceride.  Conclusions:  Antioxidant supplements are an effective intervention for relieving insulin resistance but do not significantly improve lipid metabolism in women with PCOS.

gynecological endocrinology

Antioxidant supplements relieve insulin resistance but do not improve lipid metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials