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This study aims to investigate whether  HRG  gene C633T rs9898 and  TP73  gene rs4648551 A &gt; G polymorphisms have an effect on ovulation and response to the gonadotropin treatments. Blood samples were received from a total of 206 individuals (116 patients from whom good quality and optimal of numbers oocytes have not been able to be obtained at the IVF Center of Ondokuz Mayıs University, Faculty of Medicine and 90 controls). Genomic DNA was extracted by DNA isolation and SNP genotyping was performed by real-time qPCR method. According to the results, a significant difference was observed between the patient and control groups in terms of the  TP73  gene variant, however there was no significant difference regarding  HRG  gene polymorphism. Our findings suggest that while AG genotype for  TP73  could be a genetic marker for ovarian response,  HRG  gene C633T variation is not associated with ovarian response in our cohort. Further studies with larger study groups are required to investigate possible associations of these gene variants with ovarian response.

Effects of HRG and TP73 gene variations on ovarian response