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Acute idiopathic blind spot enlargement (AIBSE) is a rare condition which is poorly understood. To our knowledge, this is the first report of acute idiopathic blind spot enlargement following covid-19 vaccination. We believe there is educational value for ophthalmologists to recognize the potential association of ocular inflammation and new mRNA vaccines.

Unilateral Acute Idiopathic Blind Spot Enlargement following Second Dose of Covid-19 mRNA Vaccine