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To report a rare case of fungal keratitis caused by  Plectosphaerella cucumerina . This study retrospectively reviewed the medical records of a case of fungal keratitis. Silt-lamp biomicroscopy revealed corneal infiltration and epithelial defects. Anterior segment optical coherence tomography (AS-OCT) and  in vivo  confocal microscopy (IVCM) were performed to assist in the diagnosis and evaluate corneal conditions. The isolate was identified as  Plectosphaerella cucumerina  by MALDI-TOF mass spectrometry. The patient was treated with topical 5% pimaricin and oral voriconazole for 1 month and recovered. Fungal keratitis caused by  Plectosphaerella cucumerina  is rare. AS-OCT and IVCM can help locate the lesion and diagnose fungal keratitis. Furthermore, MALDI-TOF mass spectrometry showed potential prospects in the identification of filamentous fungi.  Plectosphaerella cucumerina  rarely infects humans and is sensitive to antifungal agents such as pimaricin and voriconazole.

Case Report: A Rare Fungal Keratitis Caused by Plectosphaerella Cucumerina