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This case report describes an 8 year old boy unsuccessfully treated for years for Vernal Keratoconjunctivitis. We report a VKC resistant to all types of treatment known in the literature, such as topical and oral corticosteroids, topical and oral cyclosporine, immunotherapy, and third generation anti-histamine eye drops, due to unknown HIV co-infection. During further laboratory tests, patient tested positive for HIV even though he did not present any clinical manifestation of HIV disease. Only after antiretroviral treatment was started the allergy symptoms completely regressed. This case report suggests considering investigation of HIV infection in patients with refractory allergic conjunctivitis.

Vernal Keratoconjunctivitis as the Only Clinical Manifestation of HIV Infection