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The nuclear receptor coactivator 5  (NCOA5)  has been linked to several inflammatory disorders, including Behçet’s disease (BD). We evaluated the expression of  NCOA5  messenger RNA (mRNA) using real-time reverse transcription-polymerase chain reaction, and analyzed the rs2903908 T &gt; C of  NCOA5  using TaqMan allelic discrimination assay in 49 Egyptian BD patients and 50 controls. The  NCOA5  mRNA levels were higher in patients compared to controls ( p  = .02), female patients compared to males ( p  = .037), and in patients with ocular involvement ( p  = .049). Non-CC genotype carriers had a higher frequency of articular manifestations compared with CC carriers ( p  = .047). Genotypes CC + CT were associated with reduced risk of cutaneous involvement (OR = 0.27,  p  = .04). CC carriers with active BD or cutaneous manifestations displayed significantly lower  NCOA5  mRNA expression than TT carriers. Our results demonstrate that  NCOA5  is linked to BD clinical findings and activity.

ocular immunology and inflammation

Analysis of Nuclear Receptor Coactivator 5  (NCOA5)  Messenger RNA Expression and rs2903908 Single Nucleotide Polymorphism of  NCOA5  in an Egyptian Cohort with Behçet’s Disease: A Single-Center Case-control Study