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To assess the diagnostic value of brain magnetic resonance imaging (bMRI) for the etiological diagnosis of uveitis and to establish predictive factors associated with its advantageous use. Retrospective study on all patients with  de novo  uveitis who were referred to our tertiary hospital and who underwent a bMRI between 2003 and 2018. bMRI was contributive in 19 out of 402 cases (5%), among patients with a contributive bMRI, 68% had neurological signs. Univariate analysis established that neurological signs ( p  &lt; .001), granulomatous uveitis ( p  = .003), retinal vasculitis ( p  = .002), and intermediate uveitis ( p  &lt; .001) were all significantly associated with a contributive bMRI. Multivariate analysis confirms the significant association of neurological signs ( p  &lt; .001) and intermediate uveitis ( p  = .01). bMRI appears to be a relevant exam in specific cases; intermediate/posterior uveitis or panuveitis accompanied by neurological signs, retinal vasculitis, or in patients older than 40, to rule out an oculocerebral lymphoma. ACE: Angiotensin-Converting Enzyme; bMRI: Magnetic Resonance Imaging; CBC: Complete Blood cell Count; BMRI: Brain Magnetic Resonance Imaging; CT: Computerized Tomography; MS: Multiple Sclerosis; NS: Neurological Signs; OCL: Oculocerebral Lymphoma; RIS: Radiologically Isolated Syndrome

Relevance of Brain MRI in Patients with Uveitis: Retrospective Cohort on 402 Patients