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To report a case of initial-onset acute Vogt–Koyanagi–Harada (VKH) presenting with internal limiting membrane (ILM) folds as the initial clinical sign. This is a retrospective case review. A 36-year-old woman with a recent history of periorbital injection of cosmetic filler who presented with sudden blurred vision in the right eye of a few hours duration. Initial fundus examination revealed only ILM folds in the right eye. Next day, the patient developed the full ophthalmic clinical picture of initial-onset acute VKH disease. Multimodal imaging showed features of ILM undulations and acute VKH disease. Uveitis was treated successfully with systemic corticosteroids combined with mycophenolate mofetil. The patient had complete resolution of posterior segment inflammation and exudative retinal detachment. ILM folds/undulations can be one of the early signs in acute VKH disease, and may serve as an important early clinical clue for this diagnosis.

Internal Limiting Membrane Folds as a Presenting Sign in Acute Initial-Onset Vogt–Koyanagi–Harada Disease: A Case Report