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Nanofibrous scaffolds with core-shell structures can deliver bioactive agents, augment mechanical properties, provide a high surface area to volume ratio, and most importantly mimic the structure of extracellular matrix (ECM) which enables to maintain of a moist environment, elimination of excess exudates and provide antibacterial properties to impede infections. This study has developed PVA, licorice, and collagen (PLC) based hybrid bio-nano scaffold by co-axial electrospinning technique for enhancing wound closure. The core layer was made by PVA &amp; licorice extract and shell layer was created by collagen &amp; licorice extract solution. The morphology, moisture management properties, presence of constituent polymer, thermal behavior, and mechanical properties of the developed samples were characterized by FE-SEM, moisture management tester (MMT), FT/IR, TGA, tensile testing machine. Furthermore,  in vitro  antibacterial assay was conducted by Kirby-Bauer disk diffusion method for investigating antibacterial properties and an in-vivo wound healing assessment was employed by observing the wound healing. Then FE-SEM images showed the lowest and highest average diameters 119 nm and 154 nm respectively, FT/IR spectra ensured the presence of all materials in the sample. Furthermore, the moisture management test result demonstrated slow absorbing and slow drying scaffolds which emphasized the eligibility of the sample to be an ideal candidate for wound healing. Moreover, the minimum and maximum zones of inhibition (ZOI) were found 7 mm and 8 mm against the bacteria  Staphylococcus aureus . Finally, an  in vivo  wound healing assessment revealed a better healing performance of the developed samples after 10 days.

PVA, licorice, and collagen (PLC) based hybrid bio-nano scaffold for wound healing application