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Herein, we have successfully synthesized a novel  n CS-PDMA/AuNPs nanocomposite based on  nano -chitosan containing poly(2,5-dimethoxyaniline) capped gold nanoparticle  in situ  synthesis is reported. The AuNPs were synthesized using the green method without using any harmful chemicals, reducing and stabilizing agents to generate AuNPs, is not needed because these roles are played by  n CS. The synthesized  n CS-PDMA/AuNPs nanocomposite were characterized by UV-Vis, FT-IR, XRD, SEM, and TEM analysis. The polydispersed  n CS-PDMA/AuNPs nanocomposite was observed approximately 25 nm. Furthermore,  n CS-PDMA/AuNPs nanocomposite was showed significant antibacterial activity against  S. aureus  and  E. coli . The  n CS-PDMA/AuNPs nanocomposite showed strong antioxidant activity by inhibiting the DPPH radicals. In addition, the cytotoxicity of  n CS-PDMA/AuNPs nanocomposite was tested in HeLa cells and found to be high toxicity than  n CS-PDMA. This work suggests that green synthesized  n CS-PDMA/AuNPs nanocomposite may be utilized as an effective antibacterial, antioxidant, and anticancer activity. nCS-PDMA capped gold nanoparticles (nCS-PDMA/AuNPs) were prepared. Physical characterization of nCS-PDMA/AuNPs by UV-vis, FTIR, XRD, SEM, and TEM. nCS-PDMA/AuNPs displayed promising inhibitory activity against both bacteria. nCS-PDMA/AuNPs showed significant DPPH radical scavenging activities. nCS-PDMA/AuNPs showed an excellent anticancer activity against HeLa cells.

journal of biomaterials science, polymer edition

In situ  synthesis and characterization of colloidal AuNPs capped  nano -chitosan containing poly( 2,5 -dimethoxyaniline) nanocomposites for biomedical applications