Open AccessApoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex
Author(s) -
Ying Huang,
Osamu Ohno,
Kiyotake Suenaga,
Kenji Miyamoto
Publication year - 2017
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1080/09168451.2017.1300517
Subject(s) - apoptosis , chemistry , cytotoxic t cell , cytotoxicity , cell culture , pharmacology , cell growth , cortex (anatomy) , caspase 3 , caspase , traditional medicine , active ingredient , biochemistry , programmed cell death , biology , in vitro , medicine , neuroscience , genetics
Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced apoptosis selectively in the cancer cell lines. These effects were cancelled by the addition of caspase inhibitor Z-VAD-FMK, suggesting that it was mediated by caspase-3 activation.
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