Open AccessEffects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes
Author(s) -
Yoshihiro Tokudome,
Kyosuke Nakamura,
Fumie Hashimoto
Publication year - 2014
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1080/09168451.2014.910092
Subject(s) - involucrin , filaggrin , epidermis (zoology) , tissue transglutaminase , biology , messenger rna , gene expression , cellular differentiation , peptide , keratinocyte , microbiology and biotechnology , gene , biochemistry , enzyme , immunology , in vitro , atopic dermatitis , anatomy
Low molecular weight soybean peptide (LSP) was applied to normal human epidermal keratinocytes, and the results showed a significant increase in the gene expression levels of involucrin, transglutaminase, and profilaggrin. Filaggrin protein levels were also significantly higher. It is possible that LSP has an epidermal cell differentiation-promoting effect and may be able to regulate metabolism of the epidermis.
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