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This study explored the impacts of matrine on hepatocellular carcinoma (HCC) cell growth, metastasis, epithelial-mesenchymal transition (EMT), and stemness through regulating the microRNA  (miR)-299-3p / phosphoglycerate mutase 1  ( PGAM1 ) axis. The association between  miR-299-3p  expression with the prognosis of HCC patients was studied.  miR-299-3p  and  PGAM1  sequences were transfected into matrine-treated HCC cells, and cell proliferation, invasion, apoptosis, and stemness were detected, as well as protein expression of EMT- and stemness-related makers. The targeting relationship between  miR-299-3p  and  PGAM1  was identified. Matrine elevated  miR-299-3p  expression, repressed proliferation, invasion, and anti-apoptosis of HCC cells, and constrained EMT and stemness  in vitro .  PGAM1  was a target of  miR-299-3p . Repression of  PGAM1  rescued the effects of  miR-299-3p  downregulation on HCC cells. Matrine stimulates HCC cell apoptosis and represses the process of EMT and stemness through the  miR-299-3p / PGAM1  axis.

Matrine induces hepatocellular carcinoma apoptosis and represses EMT and stemness through microRNA-299-3p/PGAM1 axis