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We developed predictive formulae for the  in vitro  dissolution rate constant k dis  of acid-soluble synthetic vitreous fibers (SVF), paralleling our earlier work with glass wools, which are typically more soluble at neutral pH. Developing simple models for predicting the k dis  of a fiber can allow prediction of  in vivo  behavior, aid fiber developers, and potentially reduce  in vivo  testing. The k dis  of several acid-soluble SVF were determined using high simulant fluid flow/fiber surface area (F/A) conditions  via  a single-fiber measurement system. Four fluids were employed, varying in base composition and citrate levels. Equations predicting the k dis  were derived from fiber chemistry and dissolution measurements for two of the fluids. Testing of several fibers showed a ∼10× increase in the k dis  when citrate was included in the simulant solution. Data from tests with Stefaniak’s citrate-free Phagoloysosmal Simulant Fluid (PSF) yielded k dis  values aligned with expectations from  in vivo  results, unlike results from citrate-containing modified Gamble’s solution. Predictive equations relating fiber chemistry to k dis  showed reasonable agreement between the measured and predicted values. Citrate inclusion in the solution under high F/A conditions significantly increased the measured k dis . This resulted in more biorelevant data being obtained using the PSF fluid with the high F/A method used. The developed predictive equations, sufficient for fiber development work, require refinement before a recommending their use in place of  in vivo  biopersistence testing. Significant fit improvements are possible through additional measurements under these experimental conditions.

Predicting the in vitro dissolution rate constant of mineral wool fibers from fiber composition