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We aimed to evaluate the impact of the resection technique (tumor enucleation (TE) or standard partial nephrectomy (SPN)) on trifecta outcomes in patients having undergone partial nephrectomy (PN). We retrospectively analyzed the clinical and pathologic parameters in patients with localized renal cell carcinoma (pT1–2N0M0) who had undergone PN between January 2001–December 2018 at one of 15 different tertiary referral centers. Multivariable logistic regression analysis was applied to investigate independent predictors of trifecta failure, decreased postoperative renal functions (decreased estimated glomerular filtration rate (eGFR) &gt; 10%), perioperative complications (Clavien–Dindo &gt; 1), and positive surgical margins. A total of 1070 patients with a mean age 56.11 ± 11.88 years were included in our study. PN was performed with TE in 848 (79.25%) and SPN in 222 (20.75%) patients. Trifecta failure rate was 56.2% for TE and 64.4% for SPN ( p  = 0.028). On multivariable analysis, TE was associated with less trifecta failure ( p  = 0.025) and eGFR decrease &gt;10% rates ( p  = 0.024). On the other hand, there was no statistically significant difference between TE and SPN according to positive surgical margins ( p  = 0.450) and complication &gt; Clavien-Dindo grade 1 ( p  = 0.888) rates. The only independent predictive factor for complications &gt; Clavien–Dindo 1 was the Charlson comorbidity index (CCI) ( p  = 0.001). TE is associated with less trifecta failure than SPN. This result is mainly due to better preservation of renal function with TE.

journal of investigative surgery

Comparison of Tumor Enucleation and Standard Partial Nephrectomy According to Trifecta Outcomes: A Multicenter Study by the Turkish Academy of Urology, Uro-Oncology Working Group