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Staphylococcus aureus  forms biofilms, a structure that protects bacterial cells, conferring more resistance to difficult treatment. Synthetic peptides surge as an alternative to overcome the biofilm of multidrug-resistant pathogens.  Mo -CBP 3 -PepI, when combined with Ciprofloxacin, reduced preformed  S. aureus  biofilm by 50% at low concentrations (0.2 and 6.2 μg. mL −1 , respectively). The goal of this study was to evaluate the proteomic profile of biofilms after treatment with the  Mo -CBP 3 -PepI combined with ciprofloxacin. Here, proteomic analysis confirmed with more depth previously described mechanisms and revealed changes in the accumulation of proteins related to DNA and protein metabolism, cell wall biosynthesis, redox metabolism,  quorum  sensing, and biofilm formation. Some proteins related to DNA and protein metabolism were reduced, while other proteins, like redox system proteins, disappeared in Ciprofloxacin+ Mo -CBP 3 -PepI treatment. Our results indicated a synergistic effect of these two molecules with several mechanisms against  S. aureus  biofilm and opened new doors for combined treatments with other drugs.

biofouling

United we stand, divided we fall: in-depth proteomic evaluation of the synergistic effect of  Mo -CBP 3 -PepI and Ciprofloxacin against  Staphylococcus aureus  biofilms