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Trichosporon asahii  and  T. inkin  are emergent agents of deep-seated and disseminated infections in immunocompromised patients. The present study aimed to investigate the role of extracellular DNA (eDNA) and the enzyme deoxyribonuclease (DNase) on the structure of  T. asahii  and  T. inkin  biofilms, as well as to examine their effect on the susceptibility to antifungals. Biofilms reached maturity at 48 h; eDNA concentration in the supernatant increased over time (6 &lt; 24 h &lt; 48h). Exogenous eDNA increased biomass of  Trichosporon  biofilms at all stages of development, enhanced their tolerance to antifungals and improved their structural complexity. DNase reduced biomass, biovolume and thickness of  Trichosporon  biofilms, thereby rendering them more susceptibility to voriconazole. The results suggest the relevance of eDNA in the structure and antifungal susceptibility of  Trichosporon  biofilms and highlight the potential of DNase as adjuvant in biofilm control.

biofouling

Heterologous extracellular DNA facilitates the development of  Trichosporon asahii  and  T. inkin  biofilms and enhances their tolerance to antifungals