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Pseudomonas aeruginosa  is an opportunistic pathogen in immunocompromised patients and accounts for mortality worldwide. Quorum sensing (QS) and QS mediated biofilm formation of  P. aeruginosa  increase the severity of infection in the host. New and effective therapeutics are in high demand to eliminate  Pseudomonas  infections. The current study investigated the quorum quenching and biofilm inhibition properties of alantolactone (ATL) against  P. aeruginosa  PAO1. The production of key virulence factors and biofilm components were affected in bacteria when treated with sub-MIC of ATL and further validated by qRT-PCR studies. The anti-infective potential of ATL was corroborated in an  in vivo  model with improved survival of infected  Caenorhabditis elegans  and reduced bacterial colonization.  In silico  studies suggested the molecular interactions of ATL to QS proteins as stable. Finally, ATL was explored in the present study to inhibit QS pathways and holds the potential to develop into an effective anti-infective agent against  P. aeruginosa .

Alantolactone modulates the production of quorum sensing mediated virulence factors and biofilm formation in Pseudomonas aeruginosa