English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Dengue is a life-threatening disease. The factors that lead to severe cases are not completely understood. The host immune system is involved in the response to infections and plays an important role in dengue infection. IL-6 and iNOS are components of the immune system and genetic polymorphisms in these genes may be involved in dengue virus infection. The study aimed to investigate the association of genetic polymorphisms in the  IL6  and  iNOS  genes and dengue. Methods: We performed a case-control study using 60 dengue-infected individuals and 119 healthy controls. Polymorphisms in the  IL6  (T15A) and  iNOS  (−1173CT) genes were amplified by Real-Time PCR. Statistical analyses were performed using BioEstat 5.0. Results: We identified that the frequency of T/A genotype of  IL6  was higher in dengue fever patients and C/T genotype of  iNOS  was higher in dengue hemorrhagic fever patients, however, no association was found between these polymorphisms and dengue. Conclusion: Polymorphisms in  iNOS  and  IL6  were not associated with dengue infection.

No Association Between Interleukin 6 and Inducible Nitric Oxide Synthase Polymorphisms and Dengue Infection: A Case-Control Study