English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Defects in apoptotic cell clearance is a pathogenic factor in systemic lupus erythematosus (SLE). This study screened potential pathogenic single nucleotide polymorphisms (SNPs) related to anti-apoptosis from an SLE family and explored their contribution to SLE susceptibility in Chinese women. Four SNPs ( IKBKE  rs15672,  BANK1  rs12640056,  BANK1  rs6842661, and  NFKBIA  rs1957106) with potential SLE susceptibility were analyzed for clinical characteristics between 567 patients with SLE and 345 healthy control subjects. IKBKE  rs15672 G/A and  BANK1  rs12640056C/T polymorphisms were associated with SLE susceptibility (rs15672 A vs G,  P  = 0.028, OR = 1.25, 95% CI = 1.02–1.52; rs12640056 T vs C,  P  = 0.015, OR = 0.78, 95% CI = 0.64–0.95, respectively). In addition, patients with AA+GA genotypes of  IKBKE  rs15672 had higher positive rates of anti-SSB antibodies ( q  = 0.008) and lower positive rates of anti-RIB antibodies ( q  = 0.024) than those with the GG genotype. There were no significant differences in  BANK1  rs12640056 between different genotypes and clinical characteristics. IKBKE  rs15672 G/A and  BANK1  rs12640056C/T polymorphisms are associated with susceptibility to SLE in Chinese women. This highlights the important role of these two SNPs in this disease and suggests that multiple genes from these pathways are candidates for functional studies and therapeutic targets.

IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus