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Genetic variants in the T cell immunoglobulin and mucin domain-containing molecule 3 ( TIM-3 ) gene have been reported to be associated with the risk of cancers and patients’ outcomes. The aims of this study were to explore the role of  TIM-3  polymorphisms in the risk of colorectal cancer (CRC) and the prognosis of CRC patients in a northern Chinese population. Two polymorphisms of  TIM-3  were genotyped using polymerase chain reaction and ligase detection reaction in 364 CRC patients and 372 healthy control subjects. The levels of  TIM-3  mRNA were investigated in 65 CRC tissues by quantitative real-time PCR. The results showed that neither rs10053538 nor rs10515746 was associated with susceptibility to CRC. However, the CA+AA genotypes of rs10053538 were related to an advanced clinical stage and increased risk of lymph nodemetastasis ( P  = .046 and 0.024, respectively). Multivariate analyses performed after adjusting for clinical variables showed that patients with the CA+AA genotypes of rs10053538 exhibited a significantly shorter disease-free survival (DFS) and overall survival (OS) time compared with those carrying the CC genotype (HR = 1.91, 95% CI = 1.04–3.51; HR = 2.61, 95% CI = 1.35–5.03). In addition, the expression of  TIM-3  mRNA was significantly increased in the CRC tissues of patients carrying the rs10053538 CA+AA genotypes compared with patients carrying the CC genotype ( P  = .019). The rs10053538 may serve as an independent molecular marker for predicting the clinical outcome of CRC patients in the study population.

The TIM-3 Rs10053538 Polymorphism Is Associated with Clinical Prognosis of Colorectal Cancer